CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 15 enrolled
Drug / intervention
Intravenous Nicotine +1 moredrug
Likely dose
Intravenous Nicotine 1.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01588561
NCT01588561N/ACompleted
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Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels, an Exploratory Study

Mclean Hospital·interventional·Posted May 1, 2012·Updated Aug 31, 2017

In Brief

A clinical study evaluating Intravenous Nicotine and Saline - placebo for Nicotine Dependence. Completed, enrolled 15 participants across 1 site.

Detailed Summary

In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNicotine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 1, 2012
Enrollment StartOct 1, 2005
Primary CompletionJul 1, 2015
Study CompletionSep 1, 2015
TodayJul 2, 2026
Enrollment to primary: 9.8 yearsPosted 14.2 years ago

Interventions

Intravenous Nicotinedrug

Subjects received a single infusion of nicotine, 1.5 mg/70kg (New England Compounding Center, Framingham, MA), administered over 1 minute into the antecubital vein 10 minutes into their MRI scans.

Saline - placeboother

Subjects received a single infusion of saline, administered over 1 minute into the antecubital vein 10 minutes into their MRI scans.