CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 5 enrolled
Drug / intervention
Bimodal rTMSdevice
Likely dose
High frequency (10 Hz) rTMS at 110% motor threshold over left dorsolateral prefrontal cortex, followed by low frequency (1 Hz) rTMS at 110% motor threshold over temporoparietal junctionAI-extracted
Key inclusion· 4
  • ✓Age 18–60 years
  • ✓Subjective, idiopathic, troublesome tinnitus (unilateral or bilateral, non-pulsatile) of 2 months to 5 years duration
  • ✓Bothersome tinnitus per Tinnitus Handicap Inventory score
  • ✓English language proficiency (speak, read, write, understand)
Key exclusion· 16
  • ✕Tinnitus related to cochlear implantation, retrocochlear lesion, or structural lesions of ear and temporal bone
  • ✕History of stapedectomy with implant insertion
  • ✕Hyperacusis (hypersensitivity to noise)
  • ✕Head injury with ≥15 minutes loss of consciousness or requiring medical treatment

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01590264
NCT01590264N/ACompleted
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rTMS Bimodal Treatment For Patients With Subjective Idiopathic Tinnitus: A Pilot Study

Washington University School of Medicine·interventional·Posted May 2, 2012·Updated Apr 2, 2013

In Brief

A clinical study evaluating Bimodal rTMS for Tinnitus. Completed, enrolled 5 participants across 1 site.

Detailed Summary

Repetitive Transcranial Magnetic Stimulation (rTMS) is a novel brain stimulation technique that uses pulsating magnetic fields to stimulate underlying neurons in the cerebral cortex. The investigators propose an open-label pilot study investigating the effectiveness of rTMS in the treatment of tinnitus stimulation of the left dorsolateral prefrontal cortex (DLPFC), an area known to be important for mood and attention, along with stimulation of the left temporoparietal cortex (TPC). This is a feasibility pilot study.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTinnitus
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedMay 2, 2012
Enrollment StartMay 1, 2012
Primary CompletionSep 1, 2012
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 14.2 years ago

Interventions

Bimodal rTMSdevice

High frequency (10 Hz) at 110% of the motor threshold TMS delivered over the left dorsolateral prefrontal cortex, subsequently, a low frequency TMS (1 Hz) at 110% motor threshold will be delivered over 31 minutes over the TPJ area, according to the protocol below. DLPFC Stimulation Frequency 10 Hz Intensity 110% of motor threshold On 5 seconds Off 15 seconds Total Trains 80 per session Total pulses session 4000/session Duration session 26.6 minutes Total pulses (study) 40000 TPJ Stimulation Frequency 1 Hz Intensity 110% of motor threshold On 900 seconds Off 60 seconds Total Trains 2 per session Total Pulses session 1800 Duration session 31 minutes Total Pulses study 18000