At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 64 enrolled
Drug / intervention
Ketamine +2 moredrug
Likely dose
Ketamine 0.2 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Hydromorphone PCA or Hydromorphone PCA With Ketamine for Acute Postoperative Pain Relief in Opioid-Dependent Chronic Pain Patients
In Brief
A Phase 4 clinical trial evaluating Ketamine, Placebo, and 1 other intervention for Postoperative Pain. Completed, enrolled 64 participants across 1 site.
Detailed Summary
Patients who are dependent on opioids often have poor pain relief after major surgery. This study tests the hypothesis that adding intravenous ketamine to a postoperative regimen of intravenous opioids for postoperative pain will improve pain relief in this subset of patients.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Pain
CountriesUnited States
Collaborators--
Timeline
Phase 4CompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
Enrollment StartSep 2008
Primary CompletionJun 2011
First PostedMay 2012
Study CompletionJun 2012
TodayJul 2026
First PostedMay 4, 2012
Enrollment StartSep 1, 2008
Primary CompletionJun 1, 2011
Study CompletionJun 1, 2012
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 14.2 years ago
Interventions
Ketaminedrug
Intravenous (IV) ketamine 0.2 mg/kg/hr for 24-48 hours postoperatively.
Placebodrug
Patients who received ketamine-matching placebo were given saline infusions
Hydromorphone PCAdrug
Intravenous hydromorphone PCA