At a glance
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Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
In Brief
A clinical study evaluating ketamine infusion and Methadone PCA for Post Operative Pain and Hyperalgesia. Completed, enrolled 113 participants across 1 site.
Detailed Summary
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.
Study Details
Timeline
Interventions
Ketamine infusion scheme: 5mcg/Kg/min from induction od anaesthesia for 10 min, than 2,5mcg/Kg/min for 20 min and than 2 mcg/Kg/min to the end of surgery
Methadone administered by a PCA system (dose 2 mg, lock-out 12min.)