CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 168 enrolled
Drug / intervention
Integrated Prolonged Exposure Therapy +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01601067
NCT01601067Phase 2Completed
CompareCT.gov

Integrated Alcohol Disorder and PTSD Treatment

VA Office of Research and Development·interventional·Posted May 17, 2012·Updated Aug 8, 2019

In Brief

A Phase 2 clinical trial evaluating Integrated Prolonged Exposure Therapy and Seeking Safety for PTSD and Alcoholism. Completed, enrolled 168 participants across 1 site.

Detailed Summary

Comorbidity of alcohol use disorder (AD) and posttraumatic stress disorder (PTSD) is common. Currently available treatments often do not lead to sustained recovery from these disorders, possibly because they typically do not include exposure therapy which is considered best practice treatments for PTSD. This study compares exposure-based integrated treatment to integrated coping skills psychotherapy (a well disseminated practice) for comorbid AD and PTSD with the hypothesis that exposure therapy will allow those with PTSD to better sustain PTSD symptom reduction and reduction in alcohol use. The aim of this grant is to change common treatment practices for comorbid AD and PTSD by increasing the availability of evidence-based PTSD treatment for those with AD.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPTSD, Alcoholism
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201220132014201520162017201820192020202120222023202420252026
First PostedMay 17, 2012
Enrollment StartJan 21, 2013
Primary CompletionMar 30, 2018
TodayJul 2, 2026
Enrollment to primary: 5.2 yearsPosted 14.1 years ago

Interventions

Integrated Prolonged Exposure Therapybehavioral

Prolonged exposure (PE) therapy is an evidence based practice for the treatment of PTSD. Components of PE included education about PTSD and exposure to avoided reminders of trauma.

Seeking Safetybehavioral

Seeking Safety (SS) teaching coping skills in behavioral, cognitive, and interpersonal domains so that people are able to make safe choices rather than drinking or PTSD-related behaviors such as avoidance.