At a glance
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Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)
In Brief
A Phase 2 clinical trial evaluating 3-Dimensional Conformal Radiation Therapy, Carboplatin, and 3 other interventions for Central Nervous System Nongerminomatous Germ Cell Tumor and Childhood Germinoma. Completed, enrolled 262 participants across 167 sites in 5 countries.
Detailed Summary
This phase II trial studies how well chemotherapy followed by radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors that have not spread to other parts of the brain, spinal canal, or body (localized). Drugs used as chemotherapy, such as carboplatin, etoposide, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x rays to kill tumor cells. Giving chemotherapy followed by radiation therapy may kill more tumor cells.
Study Details
Timeline
Interventions
Undergo 3D-CRT
Given IV
Given IV
Given IV
Undergo IMRT