At a glance
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Prevention of Oversedation in Intensive Care Patients Under Mechanical Ventilation : the AWARE Multicentric Randomized Trial
In Brief
A clinical study evaluating Clinical Procedure to Prevent Oversedation and Usual sedation practice for ICU Patients Requiring Invasive Mechanical Ventilation. Completed, enrolled 1,180 participants across 43 sites.
Detailed Summary
The purpose of the present study is to determine whether administration of sedation according to a strategy including a bundle of measures to prevent oversedation is associated with a reduction in mortality of intensive care unit patients requiring mechanical ventilation, compared to administration of sedation according to usual practices.
Study Details
Timeline
Interventions
Sedation and analgesia will be administered according to a bundle of measures aimed at limiting oversedation, including repeated assessment of patients needs and graduate therapeutic response to control pain, discomfort, poor synchrony with the ventilator and agitation. The therapeutic options include non hypnotic anxiolytics, repeated IV hypnotics boluses, short-duration (6 hours) IV hypnotics infusion and round the clock IV hypnotics infusion.
Sedation and analgesia will be administered according to the usual practices in each participating center.