CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 16 enrolled
Drug / intervention
Sedation drug (Propofol and Midazolam)drug
Likely dose
Not stated in record
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Search/NCT01618396
NCT01618396N/ACompleted
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Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock

Casa de Saúde São José·interventional·Posted Jun 13, 2012·Updated Jun 13, 2012

In Brief

A clinical study evaluating Sedation drug (Propofol and Midazolam) for Shock, and Sepsis. Completed, enrolled 16 participants across 1 site.

Detailed Summary

Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these agents interfere or not on microvascular blood flow. The goal of this study was to compare effects of propofol and midazolam infusions on sublingual microcirculation of septic shock patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsShock,, Sepsis
CountriesBrazil
Collaborators--

Timeline

N/ACompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJun 13, 2012
Enrollment StartMar 1, 2011
Primary CompletionAug 1, 2011
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 14.1 years ago

Interventions

Sedation drug (Propofol and Midazolam)drug

Septic patients, after intubation, were initially sedated with propofol. During the second day of mechanical ventilation, propofol infusion was interrupted. When the patient awoke, the sedative drug was changed to midazolam. Sedation target was a Ramsay Scale score of 4 to 5.