At a glance
ClinicalIndex Comparison Record- ✓Age 9-12 years
- ✓Able to understand visual and verbal pain rating scales
- ✓Moderate mandibular dental disease bilaterally with 4-7 natural teeth per quadrant
- ✓Willing to attend 3+ clinic appointments
- ✕Allergy or sensitivity to amide local anesthetics or epinephrine
- ✕Systemic illness precluding local anesthetic or epinephrine use (liver, renal, cardiovascular disease, blood dyscrasias, psychiatric disorders)
- ✕Systemic illness interfering with healing (liver disease, blood dyscrasias, uncontrolled diabetes)
- ✕Current systemic medication interfering with healing or contraindicating local anesthetics/epinephrine
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients. A Prospective, Double-blind, Randomized, Crossover Study
In Brief
A Phase 4 clinical trial evaluating Sodium bicarbonate and Lidocaine for Pain. Completed, enrolled 20 participants across 1 site.
Detailed Summary
The purpose of this study is to determine the effectiveness of buffered local anesthesia injections to numb the gums and teeth during dental treatment. Adjusting the pH of lidocaine with sodium bicarbonate may reduce the pain of injection for both adults and children. In this study, the investigators will compare two local anesthetic preparations, a buffered anesthetic and the conventionally available anesthetic, for pain upon injection. Hypothesis: Anesthetic buffered to physiologic pH will result in a less painful injection compared to the acidic alternative used in most dental offices. This can be demonstrated by comparing two local anesthetic preparations, a buffered anesthetic and the conventionally available anesthetic, for pain upon injection.
Study Details
Timeline
Interventions
8.4% neutralizing solution
2% lidocaine with 1:100,000 ppm epinephrine