At a glance
ClinicalIndex Comparison RecordN/ACompleted· 30 enrolled
Drug / intervention
Lung Ventilation +1 moreother
Likely dose
Not stated in record
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Continued Mechanical Ventilation During CABG Operation Attenuates Systemic Immune Modulation
In Brief
A clinical study evaluating Lung Ventilation and Non-ventilated Group for Coronary Artery Disease. Completed, enrolled 30 participants across 1 site.
Detailed Summary
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Artery Disease
CountriesHungary
Collaborators--
Timeline
N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
Enrollment StartApr 2009
Primary CompletionAug 2010
First PostedJun 2012
TodayJul 2026
First PostedJun 26, 2012
Enrollment StartApr 1, 2009
Primary CompletionAug 1, 2010
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 14.0 years ago
Interventions
Lung Ventilationother
In the ventilated group, mechanical ventilation was done with the half of the initial tidal volume (i.e. 3-4 ml/kg, 250-300ml) during the aortic cross-clamp.
Non-ventilated Groupother
. In the non-ventilated group lungs were collapsed after completion of CPB until after weaning from the extracorporeal circulation.