CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 122 enrolled
Drug / intervention
Adaptive Disclosure (AD) +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01628718
NCT01628718N/ACompleted

Adaptive Disclosure: A Combat-Specific PTSD Treatment

Veterans Medical Research Foundation·interventional·Posted Jun 27, 2012·Updated Apr 9, 2020

In Brief

A clinical study evaluating Adaptive Disclosure (AD) and Cognitive Processing Therapy, cognitive version only (CPT-C) for Posttraumatic Stress Disorder. Completed, enrolled 122 participants across 2 sites.

Detailed Summary

The primary objective of this randomized controlled non-inferiority trial is to determine whether or not Adaptive Disclosure (AD), a new combat-specific psychotherapy for Post Traumatic Stress Disorder (PTSD), is as least as effective as Cognitive Processing Therapy, cognitive only version (CPT-C), in terms of its impact on deployment-related psychological health problems (specifically PTSD and depression) and functioning.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedJun 27, 2012
Enrollment StartMar 1, 2013
Primary CompletionJan 1, 2019
Study CompletionJul 1, 2019
TodayJul 2, 2026
Enrollment to primary: 5.8 yearsPosted 14.0 years ago

Interventions

Adaptive Disclosure (AD)behavioral

Adaptive Disclosure (AD) is an eight-session fully manualized and piloted intervention designed specifically for Marines with PTSD stemming from a variety of traumatic deployment experiences. The approach combines imaginal exposure to activate trauma-related emotions and beliefs and cognitive and experiential techniques to modify maladaptive interpretations of the implication of various combat and operational experiences that contribute to symptoms and dysfunction.

Cognitive Processing Therapy, cognitive version only (CPT-C)behavioral

Cognitive Processing Therapy (CPT) is a 12-session manualized therapy for posttraumatic stress disorder. The theory behind CPT conceptualizes PTSD as a disorder of "non-recovery" in which erroneous beliefs about the causes and consequences of traumatic events produce strong negative emotions and prevent accurate processing of the trauma memory and natural emotions emanating from the event. A significant contributor to the interruption of natural recovery process is the ongoing use of avoidance as a coping strategy. CPT incorporates trauma-specific cognitive techniques to help individuals with PTSD more accurately appraise these "stuck points" and progress toward recovery.