CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 15 enrolled
Drug / intervention
Ticagrelor + ASA + Bivalirudin +1 moredrug
Likely dose
Ticagrelor + ASA + Bivalirudin 180 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01642238
NCT01642238Phase 4Completed
CompareCT.gov

Randomized, Crossover Study of the Antithrombotic Effects of Ticagrelor Plus Aspirin Versus Clopidogrel Plus Aspirin When Administered With Bivalirudin

Juan J Badimon·interventional·Posted Jul 17, 2012·Updated Jul 11, 2016

In Brief

A Phase 4 clinical trial evaluating Ticagrelor + ASA + Bivalirudin and Clopidogrel + ASA + Bivalirudin for Acute Coronary Syndrome. Completed, enrolled 15 participants across 1 site.

Detailed Summary

The purpose of this study is to determine whether treatment with ticagrelor (plus aspirin and bivalirudin) is more effective than treatment with clopidogrel (plus aspirin and bivalirudin).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Coronary Syndrome
CountriesUnited States
CollaboratorsAstraZeneca

Timeline

Phase 4CompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedJul 17, 2012
Enrollment StartJul 1, 2012
Primary CompletionMar 1, 2013
Study CompletionApr 1, 2013
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 14.0 years ago

Interventions

Ticagrelor + ASA + Bivalirudindrug

Single loading dose of Ticagrelor (180 mg given as two 90 mg tablets), plus single dose of ASA (one 81 mg tablet) + bivalirudin administered as 0.75 mg/kg IV bolus followed by 1.75 mg/kg/hour for 1 hour.

Clopidogrel + ASA + Bivalirudindrug

Single loading dose of Clopidogrel (600 mg given as two 300 mg tablets), plus single dose of ASA (one 81 mg tablet) + bivalirudin administered as 0.75 mg/kg IV bolus followed by 1.75 mg/kg/hour for 1 hour.