At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Intensive Versus Standard Blood Pressure Lowering to Prevent Functional Decline in Older People
In Brief
A clinical study evaluating Anti-hypertensive therapy to SBP 130 mm Hg and Anti-hypertensive therapy to SBP 145 mm Hg for Hypertension, Systolic and Cerebrovascular Disease. Completed, enrolled 199 participants across 1 site.
Detailed Summary
This randomized clinical trial examines if lowering and maintaining 24-hour ambulatory systolic blood pressure to \<130 mmHg (intensive control) versus \<145 mmHg (standard control) slows/halts the progression of deterioration of mobility and cognitive function linked to white-matter disease (also known as white-matter hyperintensity or WMH) in patients with normal or mildly impaired mobility and cognition in subjects with detectable cerebrovascular disease (\>0.5% WMH fraction of intracranial contents). The study patients will be enrolled and randomized to one of two levels of ambulatory blood pressure control (intensive to achieve a goal 24-hour systolic blood pressure of \< 130 mmHg or standard to achieve a goal 24-hour systolic blood pressure of \< 145 mmHg) for a total of 36 months.
Study Details
Timeline
Interventions
Anti-hypertensive therapy to achieve 24 hour systolic blood pressure less than or equal to 130 mm Hg
Anti-hypertensive therapy to achieve 24 hour systolic blood pressure less than or equal to 145 mm Hg