At a glance
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Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
In Brief
A Phase 2 clinical trial evaluating Remote ischemic preconditioning, Sham remote ischemic preconditioning, and 1 other intervention for Carotid Artery Stenosis. Completed, enrolled 189 participants across 1 site.
Detailed Summary
Remote limb ischemic preconditioning (RIPC) has neuro-protective and anti-inflammatory effects on ischemia- reperfusion injury. As the extent of its effect is unknown, the investigators will use clinical outcome, serum biochemical markers and brain magnetic resonance imaging (MRI) to determine whether RIPC has neuro-protective and anti-inflammatory effects on patients undergoing carotid artery stenting.
Study Details
Timeline
Interventions
Remote ischemic preconditioning consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, which is induced by an automated cuff-inflator placed on bilateral arm and inflated to 200 mmHg for 5-min followed by deflating the cuff for 5-min.
Sham remote ischemic preconditioning consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, which is induced by an automated cuff-inflator placed on bilateral arm and inflated to 60 mmHg for 5-min followed by deflating the cuff for 5-min.
Carotid Artery Stenting is an invasive therapy of carotid artery stenosis.