At a glance
ClinicalIndex Comparison RecordN/ACompleted· 30 enrolled
Drug / intervention
Sildenafil +2 moredrug
Likely dose
Sildenafil 50 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue.
The University of Texas Medical Branch, Galveston·interventional·Posted Aug 9, 2012·Updated Jul 17, 2018
In Brief
A clinical study evaluating Sildenafil, tadalafil, and 1 other intervention for Fatigue. Completed, enrolled 30 participants across 1 site.
Detailed Summary
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body composition in older individuals. Further, we will determine whether augmentation of NO-mediated signaling reduces fatigue and fatigability.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsFatigue
CountriesUnited States
Collaborators--
Timeline
N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedAug 2012
Enrollment StartNov 2012
Primary CompletionJun 2015
TodayJul 2026
First PostedAug 9, 2012
Enrollment StartNov 1, 2012
Primary CompletionJun 1, 2015
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 13.9 years ago
Interventions
Sildenafildrug
50 mg/day for 4 weeks
tadalafildrug
10 mg/day for 4 weeks.
Placebodrug
Placebo 1 capsule per day for four weeks.