At a glance
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A Phase II Study of Metformin Plus Modified FOLFOX 6 in Patients With Metastatic Pancreatic Cancer
In Brief
A Phase 2 clinical trial evaluating metformin hydrochloride, oxaliplatin, and 3 other interventions for Acinar Cell Adenocarcinoma of the Pancreas and 3 related conditions. Completed, enrolled 50 participants across 2 sites.
Detailed Summary
This phase II trial studies how well metformin hydrochloride, leucovorin calcium, fluorouracil, and oxaliplatin work in treating patients with metastatic pancreatic cancer. Metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells
Study Details
Timeline
Interventions
Given PO
Given IV
Given IV
Given IV
Correlative studies