CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 300 enrolled
Drug / intervention
Vapocoolant +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01670487
NCT01670487N/ACompleted

Prospective,Randomized,Blinded, Comparative,Efficacy and Safety Trial of Vapocoolant (Pain Ease Medium Stream) for Intravenous Cannulation in Emergency Department Patients.

The Cleveland Clinic·interventional·Posted Aug 22, 2012·Updated Oct 27, 2025

In Brief

A clinical study evaluating Vapocoolant and Sterile water for Pain. Completed, enrolled 300 participants across 1 site.

Detailed Summary

To determine the efficacy and safety of vapocoolant stream (Pain Ease Medium Stream ) in decreasing the pain of intravenous cannulation. To compare vapocoolant stream (Pain Ease medium Stream) with control (e.g. sterile water) stream.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain
CountriesUnited States
CollaboratorsGebauer Company

Timeline

N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedAug 22, 2012
Enrollment StartOct 1, 2012
Primary CompletionNov 1, 2014
Study CompletionDec 1, 2014
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 13.9 years ago

Interventions

Vapocoolantdevice

Topical stream of 4 to 10 seconds duration to skin

Sterile waterdevice

Topical intervention of sterile water stream 4 to 10 seconds to skin.