At a glance
ClinicalIndex Comparison RecordN/ACompleted· 202 enrolled
Drug / intervention
Esophageal-pressure guided mechanical ventilation +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures (EPVent2)
In Brief
A clinical study evaluating Esophageal-pressure guided mechanical ventilation and High PEEP mechanical ventilation for Acute Respiratory Distress Syndrome. Completed, enrolled 202 participants across 14 sites in 2 countries.
Detailed Summary
This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive transpulmonary pressure (Ptp = airway pressure minus pleural pressure) throughout the ventilatory cycle will lead to an improvement in patient survival.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Respiratory Distress Syndrome
CountriesCanada, United States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI)
Timeline
N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedSep 2012
Enrollment StartOct 2012
Primary CompletionOct 2017
Study CompletionOct 2018
TodayJul 2026
First PostedSep 7, 2012
Enrollment StartOct 31, 2012
Primary CompletionOct 12, 2017
Study CompletionOct 19, 2018
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 13.8 years ago
Interventions
Esophageal-pressure guided mechanical ventilationother
High PEEP mechanical ventilationother