At a glance
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Reducing Suicidal Ideation Through Insomnia Treatment
In Brief
A Phase 4 clinical trial evaluating Zolpidem-CR and Placebo for Insomnia and 2 related conditions. Completed, enrolled 103 participants across 4 sites.
Detailed Summary
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality. We have new data indicating that (1) the link between insomnia and suicidal ideation holds true in clinical trials of depressed insomniacs, (2) dysfunctional cognitions about sleep are related to suicidal ideas, and (3) treatment of insomnia with hypnotics leads to a reduction of suicidal ideation. We now propose to test whether cautious use of hypnotics in suicidal, depressed insomniacs may reduce suicide risk in a multi-site clinical trial.
Study Details
Timeline
Interventions
Zolpidem 6.25 mg or 12.5 mg in tablet form at nighttime 15 minutes before bed for 8 weeks
Placebo in tablet form at nighttime 15 minutes before bed for 8 weeks