CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 15 enrolled
Drug / intervention
Cevimeline +1 moredrug
Likely dose
Cevimeline 30mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01690052
NCT01690052N/ACompleted
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Efficacy of Cevimeline vs. Pilocarpine in the Secretion of Saliva

University of Kentucky·interventional·Posted Sep 21, 2012·Updated Jun 4, 2018

In Brief

A clinical study evaluating Cevimeline and Pilocarpine for Dry Mouth. Completed, enrolled 15 participants across 1 site.

Detailed Summary

The main objectives were: 1) To determine the efficacy of both cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia, and 2) To compare the side-effects between the treatment for xerostomia with cevimeline and with pilocarpine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDry Mouth
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedSep 21, 2012
Enrollment StartJan 1, 2009
Primary CompletionJun 1, 2010
Study CompletionJul 1, 2010
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 13.8 years ago

Interventions

Cevimelinedrug

Cevimlenine Vs Pilocarpine, cross over design. Two sequences were evaluated "cevimeline first, then pilocarpine" and "pilocarpine first, then cevimeline". Each sequence was evaluated for 4 weeks with one week "washout" period in between both sequences. 15 patients were randomly assigned to a specific sequence by a research pharmacist independent from the study authors. The patients received 30mg of cevimeline three times a day and pilocarpine 5mg three times a day.

Pilocarpinedrug

Cevimlenine Vs Pilocarpine, cross over design, 4 weeks, one week wash out