CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 250 enrolled
Drug / intervention
Apremilast +3 moredrug
Likely dose
Apremilast 30 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01690299
NCT01690299Phase 3Completed

A Phase 3B, Multicenter, Randomized, Placebo-Controlled, Double-Blind, Double-Dummy, Study Of The Efficacy And Safety Of Apremilast (CC-10004), Etanercept, And Placebo, In Subjects With Moderate To Severe Plaque Psoriasis

Amgen·interventional·Posted Sep 21, 2012·Updated Mar 15, 2022

In Brief

A Phase 3 clinical trial evaluating Apremilast, Etanercept, and 2 other interventions for Psoriasis and Psoriatic Arthritis. Completed, enrolled 250 participants across 82 sites in 11 countries.

Detailed Summary

This study will test the clinical effectiveness and safety of apremilast compared with placebo as well as etanercept compared with placebo in the same group of patients with moderate to severe plaque psoriasis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Belgium, Canada, Czechia, Estonia, Germany, Hungary, Latvia, Netherlands, United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedSep 21, 2012
Enrollment StartOct 1, 2012
Primary CompletionJul 3, 2014
Study CompletionApr 4, 2016
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 13.8 years ago

Interventions

Apremilastdrug

Apremilast 30 mg tablet orally BID

Etanerceptdrug

Etanercept 50 mg evaluator/subject-blinded SC QW injection

Placebo tabletdrug

Placebo tablets BID

Placebo injectiondrug

Once weekly evaluator/subject-blinded SC placebo (1 mL x 2 injections SC)