CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 10 enrolled
Drug / intervention
Amphetaminedrug
Likely dose
Amphetamine 0.5mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01699607
NCT01699607N/ACompleted
CompareCT.gov

Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion

Yale University·interventional·Posted Oct 3, 2012·Updated Mar 6, 2020

In Brief

A clinical study evaluating Amphetamine for Nicotine Dependence and Healthy. Completed, enrolled 10 participants across 1 site.

Detailed Summary

A research study designed to examine amphetamine-induced dopamine release using the PET imaging agent \[11C\]PHNO in tobacco smokers while currently smoking and during acute withdrawal and in nonsmokers. Twenty healthy men and women tobacco smokers and twenty healthy nonsmokers will be recruited. Each subject will participate in 1 MRI and up to 2 \[11C\]PHNO PET scans. On the study day subjects will participate in two \[11C\]PHNO scans (ideally, the two PET scans will be carried out in the same day). Three hours before the second PET scan, amphetamine (0.5 mg/kg, PO) will be administered. In smokers, the scan will occur at 10-21 days of smoking abstinence.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNicotine Dependence, Healthy
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH), National Cancer Institute (NCI)

Timeline

N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedOct 3, 2012
Enrollment StartJun 1, 2012
Primary CompletionJul 1, 2013
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 13.7 years ago

Interventions

Amphetaminedrug

All subjects will receive amphetamine to induce elevated dopamine levels in the brain at 0.5mg/kg