At a glance
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Optimal Dose of Spinal Mepivacaine Combined With Fentanyl For Knee Arthroscopy
In Brief
A clinical study evaluating Mepivacaine (24 mg) plus fentanyl, Mepivacaine (27 mg) plus fentanyl, and 2 other interventions for Arthroscopic Knee Surgery. Completed, enrolled 56 participants across 1 site.
Detailed Summary
Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around nerves, blocks nerve conduction, resulting in numbness and weakness) used in the spine, but too low a dose can result in an incomplete block (inadequate anesthesia) in some patients. There is evidence that adding a low dose of fentanyl, a narcotic, to mepivacaine enhances the anesthetic effect. The purpose of this study is to determine the lowest dose of mepivacaine, a local anesthetic, when combined with fentanyl, for which spinal anesthesia is adequate for ambulatory knee arthroscopy.
Study Details
Timeline
Interventions
Mepivacaine (24 mg) and fentanyl (10 µg)
Mepivacaine (27 mg) and fentanyl (10 µg)
Mepivacaine (30 mg) and fentanyl (10 µg)
Mepivacaine 37.5 mg