At a glance
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Early Life Stress and Depression: Molecular and Functional Imaging Approaches
In Brief
A Phase 1 clinical trial evaluating Amisulpride and Placebo for Major Depressive Disorder (MDD) and History of Childhood Sexual Abuse (CSA). Completed, enrolled 153 participants across 2 sites.
Detailed Summary
The purpose of this study is to investigate brain pathways within adult females (with a history of CSA that occurred between the ages of 5-14) with and without a current diagnosis of major depressive disorder (MDD). Hypotheses: The CSA/MDD participants will be characterized by (1) reduced reward responsiveness and prefrontal cortex activity, but increased cortisol levels, (2) reduced dopamine activity, and (3) reduced dopamine transporter binding. The over-arching purpose of the study is to (1) identify individuals at risk for psychopathology and maladaptive behavior, (2) prevent re-victimization, and (3) develop more targeted therapeutic interventions.
Study Details
Timeline
Interventions
single low-dose pharmacological challenge, 50 mg amisulpride during the fMRI session only
single-dose placebo capsule during the fMRI session only