CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 24 enrolled
Drug / intervention
Hypofractionated Radiosurgeryradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01705548
NCT01705548N/ACompleted
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Phase I Dose Escalation Trial of Hypofractionated Radiosurgery for Large Brain Metastasis

Emory University·interventional·Posted Oct 12, 2012·Updated May 7, 2026

In Brief

A clinical study evaluating Hypofractionated Radiosurgery for Metastatic Malignant Neoplasm to Brain and Unspecified Adult Solid Tumor, Protocol Specific. Completed, enrolled 24 participants across 2 sites.

Detailed Summary

This phase I trial studies the side effects and best dose of hypofractionated radiosurgery in treating patients with large brain metastasis. Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. Giving fractionated stereotactic radiosurgery may kill more tumor cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetastatic Malignant Neoplasm to Brain, Unspecified Adult Solid Tumor, Protocol Specific
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH), National Cancer Institute (NCI)

Timeline

N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedOct 12, 2012
Enrollment StartSep 24, 2012
Primary CompletionApr 11, 2023
Study CompletionSep 18, 2023
TodayJul 2, 2026
Enrollment to primary: 10.5 yearsPosted 13.7 years ago

Interventions

Hypofractionated Radiosurgeryradiation

Radiation Therapy will consist of partial brain irradiation delivered to the metastatic brain tumor or resection cavity, delivered in 5 treatments with 2-3 treatments delivered per week.