At a glance
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Preoperative Gabapentin for Reduction of Post-tonsillectomy Pain in Children
In Brief
A clinical study evaluating Gabapentin and liquid placebo for Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy. Completed, enrolled 36 participants across 1 site.
Detailed Summary
The typical post-operative course for children following surgical removal of their tonsils and adenoids can be challenging, especially for pain control. First line medications for pain include intravenous and enteral narcotics, acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) or N-methyl-D-aspartate (NMDA) antagonists but their effects appear to be short-lived. Gabapentin has been shown in adult studies to tone down the body's response to pain and decreases opioid use post-operatively. The purpose of this study is to see if a single preoperative dose will reduce post-operative pain scores and the amount of analgesic used.
Study Details
Timeline
Interventions
The active comparator, Gabapentin, is a structural analog of g-aminobutyric acid which has anticonvulsant properties. This study is a prospective randomized double-blinded trial examining the effectiveness of a single dose of liquid Gabapentin given 60 minutes prior to surgery for pain management in pediatric tonsillectomy/adenoidectomy pediatric patients.
Subjects randomized to the liquid placebo will receive an identical appearing liquid placebo of 0.4mL/kg.