At a glance
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Norwegian Intensive Care Unit Dalteparin Effect Study
In Brief
An observational study evaluating Continuous venovenous hemodialysis for Acute Kidney Injury and Deep Venous Thrombosis. Completed, enrolled 70 participants across 1 site.
Detailed Summary
The main purpose of the NORIDES study is to investigate the effect of pharmacological thromboprophylaxis with low molecular weight heparins (LMWHs) in critically ill patients, and how it is affected by presence of acute kidney injury (AKI) and treatment with hemodialysis. The main objective is to compare the prophylactic effect of dalteparin in intensive care unit (ICU) patients with AKI and Citrate-Calcium dialysis (CiCa-dialysis) with a control group of ICU patients with normal kidney function. Our main hypothesis is that CiCa-dialysis reduces dalteparin effect, and that patients undergoing CiCa-dialysis do not achieve adequate prophylaxis against venous thromboembolism (VTE). The primary endpoint is development of DVT during ICU stay, the secondary endpoint inadequate heparin effect measured in blood samples.
Study Details
Timeline
Interventions
Continuous venovenous hemodialysis