At a glance
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Intravesical Liposomes for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)
In Brief
A clinical study evaluating Liposomes for Interstitial Cystitis and Pelvic Pain. Completed, enrolled 14 participants across 1 site.
Detailed Summary
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a poorly understood chronic disorder of unknown etiology consisting of irritative bladder symptoms and pelvic pain that dramatically affects quality of life. Preclinical study data (obtained by using an IC/PBS model in Sprague-Dawley female rats) have demonstrated normalization of urinary frequency indicating that LP may be a potent protectant of the bladder mucosa against inflammation and irritation. Intravesical LP has so far demonstrated an excellent safety profile and minimal toxicity at concentrations of 2 mg/ml. Thus, we hypothesize that intravesical instillation of LP may form a molecular film on bladder ulcer surfaces in patients with IC and provide a safe, effective, and minimally invasive treatment option to alleviating symptoms.
Study Details
Timeline
Interventions
Intravesical instillation of liposomes.