At a glance
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A Prospective, Randomized, Double-Blinded Study to Evaluate the Efficacy of Intravenous Dexamethasone for Nausea Prophylaxis Prior to Duramorph and Bupivacaine Spinal Anesthesia for Scheduled Cesarean Section
In Brief
A Phase 4 clinical trial evaluating Dexamethasone and Placebo for Postoperative Nausea and Vomiting. Completed, enrolled 122 participants across 1 site.
Detailed Summary
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic. The investigators will then compare the incidence of nausea and vomiting and the use of rescue anti-nausea medications in both groups. Our hypothesis is that patients receiving dexamethasone prior to duramorph containing spinal anesthesia for cesarean section will have a significantly lower incidence and severity of PONV at 0, 1, 3, 6, and 24 hours following surgery.
Study Details
Timeline
Interventions
8mg IV dexamethesone given
Subjects randomized to placebo receive 50cc normal saline