CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 15 enrolled
Drug / intervention
Paroxetine CR for Major Depressive Episode +1 moredrug
Likely dose
Paroxetine CR for Major Depressive Episode 25mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01748955
NCT01748955Phase 4Completed
CompareCT.gov

SSRI Versus Bupropion in High-Risk Major Depressive Disorder

New York State Psychiatric Institute·interventional·Posted Dec 13, 2012·Updated Nov 21, 2017

In Brief

A Phase 4 clinical trial evaluating Paroxetine CR for Major Depressive Episode and Bupropion XL for Major Depressive Episode for Depression and Suicidal Ideation. Completed, enrolled 15 participants across 1 site.

Detailed Summary

This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted suicide or are currently experiencing suicidal thoughts.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Suicidal Ideation
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 4CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 13, 2012
Enrollment StartJun 1, 2010
Primary CompletionMar 1, 2015
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 13.6 years ago

Interventions

Paroxetine CR for Major Depressive Episodedrug

Dosage will be 25mg every day for 2 weeks, then 37.5mg every day for 2 weeks, and then optional increase to 50mg every day for the remainder of treatment.

Bupropion XL for Major Depressive Episodedrug

Dosage will be 150mg every day for 2 weeks, then 300mg every day for 2 weeks, and then optional increase to 450mg every day for the remainder of treatment.