CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 141 enrolled
Drug / intervention
Dexmedetomidine +1 moredrug
Likely dose
Saline 0.25mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01774305
NCT01774305Phase 4Completed
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Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy

Yonsei University·interventional·Posted Jan 23, 2013·Updated Feb 10, 2014

In Brief

A Phase 4 clinical trial evaluating Dexmedetomidine and Saline for Coughing. Completed, enrolled 141 participants across 1 site.

Detailed Summary

Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia. In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoughing
CountriesSouth Korea
Collaborators--

Timeline

Phase 4CompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedJan 23, 2013
Enrollment StartDec 1, 2012
Primary CompletionJan 1, 2013
Study CompletionJun 1, 2013
TodayJul 2, 2026
Enrollment to primary: 1 monthPosted 13.4 years ago

Interventions

Dexmedetomidinedrug

We administrate the dexmedetomidine single bolus (0.5ug/kg, intravenously) at time of muscle layer closing.

Salinedrug

We administrate the normal saline (single bolus, 0.25ml/kg) intravenously at time of muscle layer closing.