At a glance
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Anti-inflammatory Effects of Macrolide Treatment in Influenza Lower Respiratory Tract Infections
In Brief
A Phase 4 clinical trial evaluating Macrolide treatment for Influenza and Lower Respiratory Tract Infection. Completed, enrolled 68 participants across 2 sites.
Detailed Summary
Influenza lower respiratory tract infection (LRTI) is a major cause of morbidity and mortality worldwide. While viral replication can be suppressed by antiviral treatment, excessive inflammatory responses, which are increasingly recognized to contribute to severe influenza complications, remain unopposed. Macrolides have been used widely to treat community-acquired pneumonia, and shown to exert anti-inflammatory effects in other respiratory diseases, providing clinical benefits. In this randomized, open-label, multicenter study, we aim to investigate the anti-inflammatory effects of macrolide treatment in influenza LRTI. Its impacts on the cytokine response, viral clearance, symptoms and disease resolution will be studied. Such results may lead to the development of new therapeutic approaches against severe influenza infection, and provide better insights into disease pathogenesis.