CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 7,850 enrolled
Drug / intervention
Sulfonylurea (glimepiride) +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01794143
NCT01794143Phase 3Completed
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Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study

GRADE Study Group·interventional·Posted Feb 18, 2013·Updated Feb 10, 2026

In Brief

A Phase 3 clinical trial evaluating Sulfonylurea (glimepiride), DPP-4 inhibitor (sitagliptin), and 2 other interventions for Type 2 Diabetes and Comparative Effectiveness of Glycemia-lowering Medications. Completed, enrolled 7,850 participants across 36 sites.

Detailed Summary

The GRADE Study is a pragmatic, unmasked clinical trial that will compare commonly used diabetes medications, when combined with metformin, on glycemia-lowering effectiveness and patient-centered outcomes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsType 2 Diabetes, Comparative Effectiveness of Glycemia-lowering Medications
CountriesUnited States
CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Heart, Lung, and Blood Institute (NHLBI), Centers for Disease Control and Prevention

Timeline

Phase 3CompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedFeb 18, 2013
Enrollment StartMay 1, 2013
Primary CompletionApr 30, 2021
TodayJul 2, 2026
Enrollment to primary: 8.0 yearsPosted 13.4 years ago

Interventions

Sulfonylurea (glimepiride)drug

Used in accordance with labeling and/or usual practice.

DPP-4 inhibitor (sitagliptin)drug

Used in accordance with labeling and/or usual practice

GLP-1 receptor agonist (liraglutide)drug

Used in accordance with labeling and/or usual practice.

Insulin (glargine)drug

Used in accordance with labeling and/or usual practice.