At a glance
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Effect of Botox and Vibration on Bone in Children With Cerebral Palsy
In Brief
A clinical study evaluating Low-magnitude vibration and Botox for Cerebral Palsy and Muscle Spasticity. Completed, enrolled 29 participants across 2 sites.
Detailed Summary
Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. An estimated 70-80% of these individuals have spasticity which affects ambulation and requires management. Therefore, the treatment of spasticity is a primary goal of interventions for children with CP. One treatment widely used to reduce spasticity is Botox because of its ability to temporarily paralyze a muscle. However, no studies have determined the effect of Botox treatment on bone in humans. Also, a low magnitude vibration treatment has been shown to improve bone structure in the lower extremity bones of children with CP. The aims of this study are: 1) to determine the effect of Botox treatment in conjunction with a daily vibration treatment on bone mass and bone structure in children with spastic CP, and 2) to identify the mechanism that underlies the effect of Botox and vibration on bone.
Study Details
Timeline
Interventions
Children will receive a daily low-magnitude vibration treatment.
Children who are candidates to receive Botox as part of their standard of care.