At a glance
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Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis
In Brief
A clinical study evaluating Biopsy of the retrocrycoid laryngeal mucosa and Biopsy of the distal esophageal mucosa for Gastroesophageal Reflux Disease and Chronic Laryngitis. Completed, enrolled 24 participants across 1 site.
Detailed Summary
* Saliva plays an important role in the homeostasis of the digestive tract mucosa. * Salivary organic components, such as the Epidermal Growth Factor(EGF) have been found in defficient concentrations in patients with gastroesophageal reflux disease (GERD) and reflux related laryngitis (LPR). * The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells * Eperdermal growth factor receptor (EGFR) overexpression has been linked to hyperproliferative diseases. * It is unknown if the inflammatory process in GERD is realated to difficiencies in EGFR expression. * The objective of the current study was to try to establish a correlation between the expression of EGFR in the laryngeal and esophageal mucosa and the severity of laryngitis in adults with GERD and LPR
Study Details
Timeline
Interventions
Biopsies of the retrocrycoid laryngeal mucosa were performeed under sedation using a forceps introduced by the working channel of the endoscope
Biopsies were performeed under sedation using a forceps introduced by the working channel of the endoscope during upper digestive endoscopy