At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Myeloproliferative Neoplasms: an In-depth Case-control Study
In Brief
An observational study evaluating Methodological pens, Methodological compensation, and 1 other intervention for Polycythemia Vera and 2 related conditions. Completed, enrolled 234 participants across 3 sites.
Detailed Summary
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated a wide range of potential medical, environmental and occupational risk factors. However, these studies have been limited by a wide variation in case definition and small sample sizes limiting the potential to detect modest risk differences between cases and controls. The research group propose an exploratory case-control study of 100 patients with classic MPNs and 200 controls to determine the optimal methods for roll out of this study to a multi-centred UK-based case-control study that will investigate the aetiology of MPN subtypes. The objectives of the study are to evaluate recruitment procedures, response rates and the development of a telephone administered questionnaire. The findings of this exploratory study will form the basis of a protocol for a large United Kingdom (UK)-wide case-control study of MPNs.
Study Details
Timeline
Interventions
Randomisation of branded pen, non-branded pen and no pen
Randomisation of a £10 monetary reimbursement for expenses on completion of the study
Trolley tokens to be randomly assigned to half of cases and General Practice controls.