CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 144 enrolled
Drug / intervention
Sevoflurane +1 moredrug
Likely dose
Not stated in record
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Search/NCT01878656
NCT01878656Phase 4Completed
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Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery

Chung-Ang University Hosptial, Chung-Ang University College of Medicine·interventional·Posted Jun 17, 2013·Updated May 7, 2014

In Brief

A Phase 4 clinical trial evaluating Sevoflurane and Desflurane for Emergence Agitation. Completed, enrolled 144 participants across 1 site.

Detailed Summary

Emergence agitation is a major concern in patients undergoing orthognathic surgery. The patients may experience the sense of suffocation during emergence due to nasotracheal intubation and orofacial edema. Postoperative pain is also associated with emergence agitation. Although there is a lot of studies about emergence agitation in children, there is a few in adults, furthermore, no data about comparison of emergence agitation between sevoflurane and desflurane anesthesia in adults. Therefore, the investigators would like to compare the incidence and severity of emergence agitation between sevoflurane and desflurane anesthesia in adults after orthognathic surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsEmergence Agitation
CountriesSouth Korea
Collaborators--

Timeline

Phase 4CompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedJun 17, 2013
Enrollment StartApr 1, 2013
Primary CompletionFeb 1, 2014
TodayJul 2, 2026
Enrollment to primary: 10 monthsPosted 13.0 years ago

Interventions

Sevofluranedrug

The investigators decrease to 1 minimal alveolar concentration(MAC) of anesthetic combination of sevoflurane and nitrous oxide, and maintain end-tidal concentration of anesthetic combination at 1 MAC until the end of surgery. At the end of surgery, sevoflurane and nitrous oxide are discontinued.

Desfluranedrug

The investigators decrease to 1 MAC of anesthetic combination of desflurane and nitrous oxide, and maintain end-tidal concentration of anesthetic combination at 1 MAC until the end of surgery. At the end of surgery, desflurane and nitrous oxide are discontinued.