At a glance
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Pathophysiology and Treatment of Bipolar Disorder as Assessed by in Vivo Imaging
In Brief
A clinical study evaluating Lithium and Lamotrigine for Bipolar Disorder and 2 related conditions. Completed, enrolled 76 participants across 1 site.
Detailed Summary
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2. Assess the effect of lithium treatment of bipolar disorder on 5-HTT. 3. Assess the effect of lithium treatment of bipolar disorder on 5-HT1A BP. 4. Assess the effect of lamotrigine treatment of bipolar disorder on 5-HTT and 5-HT1A BP. 5. Assess the effect of lithium treatment of unipolar depression on 5-HTT BP.