CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 31 enrolled
Drug / intervention
Ketamine +1 moredrug
Likely dose
Methohexital 1mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01881763
NCT01881763Phase 4Completed
CompareCT.gov

Comparing Therapeutic Efficacy and Cognitive Side Effects of Electroconvulsive Therapy (ECT) Using Ketamine Versus Methohexital Anesthesia

Northwell Health·interventional·Posted Jun 20, 2013·Updated Mar 9, 2023

In Brief

A Phase 4 clinical trial evaluating Ketamine and Methohexital for Unipolar Depression and Bipolar Depression. Completed, enrolled 31 participants across 1 site.

Detailed Summary

The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients. The investigators hypothesize that patients who receive ketamine anesthesia during ECT will achieve remission status faster than those receiving methohexital anesthesia. Also, at the end of the ECT course subjects will display fewer cognitive side effects compared to those treated with methohexital anesthesia.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsUnipolar Depression, Bipolar Depression
CountriesUnited States
CollaboratorsNational Alliance for Research on Schizophrenia and Depression

Timeline

Phase 4CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedJun 20, 2013
Enrollment StartJun 1, 2010
Primary CompletionMar 1, 2017
Study CompletionJul 1, 2017
TodayJul 2, 2026
Enrollment to primary: 6.8 yearsPosted 13.0 years ago

Interventions

Ketaminedrug

Ketamine 1-2 mgr/ kg IV

Methohexitaldrug

Methohexital 0.5-1mg/kg IV