At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-Dose or Standard-Dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
In Brief
A Phase 2 clinical trial evaluating Transoral surgery, intensity-modulated radiation therapy, and 2 other interventions for Human Papilloma Virus Infection and 3 related conditions. Active but no longer recruiting, targeting 519 participants across 58 sites.
Detailed Summary
This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy with chemotherapy may kill any tumor cells that remain after surgery. It is not yet known how much extra treatment needs to be given after surgery.
Study Details
Timeline
Interventions
Undergo transoral surgical resection
Undergo standard-dose or low-dose IMRT
Given IV
Given IV