At a glance
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The Influence of Anesthetic Technique on Interleukin Plasma Level in Colorectal Cancer Surgery - TIVA vs Inhalation Anesthesia
In Brief
An observational study evaluating blood sampling for IL measurement for Colorectal Neoplasms. Completed, enrolled 70 participants across 1 site.
Detailed Summary
Knowing the fact that the anesthetic substances can alter the immune response during the surgery, the purpose of the study is to evaluate the influence of two general anesthetic techniques - inhalation vs. total intravenous anesthesia on the immune response in patient with colorectal surgery for neoplastic disease, evaluated by the plasma level of the interleukins 6 and 10(IL6, IL10).
Study Details
Timeline
Interventions
Blood sampling to determine interleukins IL6 , IL10 plasma levels are drawn at the following moments: * T0- before the induction of anesthesia (venous cannula insertion time) * T1- after induction but before starting surgery * In the group I (TIVA -TCI) when the plasma concentration of propofol is 3-3.5 ng/ml * In group II (ISOFLURANE) when concentration of isoflurane in exhaled air (Et Isoflurane) is between 0.3-0.5% * T2, T3- at 2 and 24 hours after surgery