At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence
In Brief
A Phase 1 clinical trial evaluating [11C]flumazenil and Tiagabine for Alcoholism. Completed, enrolled 11 participants across 1 site.
Detailed Summary
Background: \- This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system. It helps induce relaxation and sleep and balances the brain by inhibiting over-excitation. Several studies have reported that anxiety disorders such as panic attacks, seizure disorders, and numerous other conditions including addiction, are all related to low GABA activity. Therefore, we will examine differences in GABA levels between healthy controls and subjects with alcohol addiction. Studies such as this are important to the understanding of the role of GABA in alcohol addiction.
Study Details
Timeline
Interventions
\[11C\]flumazenil is a radiotracer used to measure levels of the neurotransmitter GABA in the human brain.
Tiagabine raises levels of GABA in the brain. It is used in this study so that we can measure the changes in GABA levels.