At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase 1 Study of AZD1775 (MK-1775) Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas
In Brief
A Phase 1 clinical trial evaluating Adavosertib, Laboratory Biomarker Analysis, and 2 other interventions for Anaplastic Astrocytoma and 5 related conditions. Completed, enrolled 46 participants across 24 sites in 2 countries.
Detailed Summary
This phase I trial studies the side effects and the best dose of adavosertib when given together with local radiation therapy in treating children with newly diagnosed diffuse intrinsic pontine gliomas. Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Giving adavosertib with local radiation therapy may work better than local radiation therapy alone in treating diffuse intrinsic pontine gliomas.
Study Details
Timeline
Interventions
Given PO
Correlative studies
Correlative studies
Undergo radiation therapy