CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 251 enrolled
Drug / intervention
BYM338/bimagrumab +1 moredrug
Likely dose
BYM338/bimagrumab 150 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01925209
NCT01925209Phase 3Completed

A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group, Dose-finding, Pivotal, Phase 2b/3 Study to Evaluate the Efficacy, Safety, and Tolerability of Intravenous BYM338 at 52 Weeks on Physical Function, Muscle Strength, and Mobility and Additional Long Term Safety up to 2 Years in Patients With Sporadic Inclusion Body Myositis

Novartis Pharmaceuticals·interventional·Posted Aug 19, 2013·Updated Aug 11, 2017

In Brief

A Phase 3 clinical trial evaluating BYM338/bimagrumab and Placebo for Sporadic Inclusion Body Myositis. Completed, enrolled 251 participants across 38 sites in 10 countries.

Detailed Summary

This study evaluated the efficacy, safety and tolerability of multiple doses of bimagrumab/BYM338 vs placebo, when administered intravenously (i.v.), on physical function, muscle strength, and mobility in patients with sporadic inclusion body myositis (sIBM).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Belgium, Denmark, France, Italy, Japan, Netherlands, Switzerland, United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedAug 19, 2013
Enrollment StartSep 26, 2013
Primary CompletionJan 6, 2016
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 12.9 years ago

Interventions

BYM338/bimagrumabdrug

BYM338, a 150 mg/mL concentrate for solution for i.v. infusion, was provided in colorless glass vials with a rubber stopper and aluminum flip-off caps.

Placebodrug

Matching placebo to BYM338 was provided in colorless glass vials with a rubber stopper and aluminum flip-off caps.