At a glance
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Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
In Brief
A clinical study evaluating Reduced Nicotine Content Cigarettes and Usual Nicotine Content Cigarettes for Tobacco Dependence. Completed, enrolled 245 participants across 2 sites.
Detailed Summary
The overall aim of this project is to evaluate the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxin exposure and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders. Smokers with mood and/or anxiety disorder will smoke research cigarettes that will contain either a) nicotine content similar to their preferred usual brand of cigarettes, or b) nicotine content per cigarette that is progressively reduced from approximately 11.6 mg to 0.2 mg per cigarette over 18 weeks. It is our hypothesis that nicotine intake will decline as a function of cigarette nicotine content in the Reduced Nicotine Content group without significant increases in tobacco smoke exposure, severity of nicotine withdrawal symptoms, mood and anxiety symptomatology or protocol non-adherence over time in the Reduced Nicotine Content group as compared with the control group.
Study Details
Timeline
Interventions
Research cigarettes will have gradually reduced nicotine content
Usual Nicotine Content Cigarettes