CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 84 enrolled
Drug / intervention
lidocaine following cue-induced craving +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01929343
NCT01929343Phase 2Completed
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Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

Bryon Adinoff·interventional·Posted Aug 27, 2013·Updated Dec 31, 2020

In Brief

A Phase 2 clinical trial evaluating lidocaine following cue-induced craving, lidocaine following neutral stimulus, and 1 other intervention for Cocaine Addiction. Completed, enrolled 84 participants across 1 site.

Detailed Summary

We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue memories. This will lead to a reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and basal craving.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCocaine Addiction
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedAug 27, 2013
Enrollment StartJan 1, 2014
Primary CompletionMar 1, 2016
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 12.8 years ago

Interventions

lidocaine following cue-induced cravingdrug

as described in Arm Description

lidocaine following neutral stimulusdrug

as described in Arm Description

salinedrug

as described in Arm Description