CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 150 enrolled
Drug / intervention
Gravitational sympathetic stimulusother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01930669
NCT01930669N/ACompleted
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Transplanted-like Heart in Critical Ill Patients

ASST Fatebenefratelli Sacco·interventional·Posted Aug 29, 2013·Updated Nov 5, 2014

In Brief

A clinical study evaluating Gravitational sympathetic stimulus for Autonomic Nervous System Dysfunction in Critically Ill. Completed, enrolled 150 participants across 2 sites.

Detailed Summary

The purpose of this study is to measure the dysfunction of the autonomic nervous system in modulating the heart rate variability and baroreflex control in critically ill.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAutonomic Nervous System Dysfunction in Critically Ill
CountriesItaly
CollaboratorsRegione Lombardia

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedAug 29, 2013
Enrollment StartAug 1, 2013
Primary CompletionSep 1, 2014
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 12.8 years ago

Interventions

Gravitational sympathetic stimulusother

Autonomic nervous system (ANS) activity is assessed by means of HRV, SAP variability and baroreflex control analysis daily from day 1 to discharge from ICU or day 28. Analysis is performed (i)at rest in supine position with bed at zero degrees of inclination (ii) during modified tilt (MTILT) and (iii) recovery from MTILT in supine position at zero degrees. In a subgroup of patients motor sympathetic nervous activity (MSNA) is recorded at day 1,2 and 7. MTILT consists in elevating head and trunk of patients at 60 degrees and lowering legs at 15 degree with a standard critical care bed. MSNA is recorded from the external peroneal nerve with microneurographic technique.