CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 18 enrolled
Drug / intervention
Hypertonic saline (3%) +1 moredrug
Likely dose
Hypertonic saline (3%) 3mLfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01945944
NCT01945944Phase 2Completed
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Nebulized Hypertonic Saline for Mechanically Ventilated Children

University Hospitals Cleveland Medical Center·interventional·Posted Sep 19, 2013·Updated Jun 28, 2016

In Brief

A Phase 2 clinical trial evaluating Hypertonic saline (3%) and Placebo (0.9% saline) for Respiratory Failure. Completed, enrolled 18 participants across 1 site.

Detailed Summary

Children who need to be on a ventilator often have thick secretions/mucus in their lungs. These secretions can obstruct the breathing tube and their windpipe, which can worsen lung function and prolong the need for the ventilator. Hypertonic saline is a medicine that is used to thin out secretions in patients with cystic fibrosis (and other conditions). We hypothesize that having children on a ventilator inhale this medication will shorten the amount of time that they need to be on the ventilator.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsRespiratory Failure
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedSep 19, 2013
Enrollment StartOct 1, 2013
Primary CompletionApr 1, 2014
Study CompletionMay 1, 2014
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 12.8 years ago

Interventions

Hypertonic saline (3%)drug

3mL of HTS given via nebulizer every 6hrs

Placebo (0.9% saline)drug

3mL of normal saline given via nebulizer every 6hrs