CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 468 enrolled
Drug / intervention
Discontinuation of treatment according to CRP levels +2 moredrug
Likely dose
Discontinuation of treatment according to CRP levels 100 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01964495
NCT01964495N/ACompleted
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Reduction of Antibiotic Therapy by Biomakers in Patients With CAP Episodes (REDUCE Study)

Medical Center Alkmaar·interventional·Posted Oct 17, 2013·Updated Apr 5, 2022

In Brief

A clinical study evaluating Discontinuation of treatment according to CRP levels, Discontinuation of treatment according to PCT levels, and 1 other intervention for Community Acquired Pneumonia. Completed, enrolled 468 participants across 3 sites.

Detailed Summary

The purpose of this study is to evaluate two different treatment strategies in patients admitted to hospital with Community Acquired Pneumonia. The investigators hypothesize treatment according to both procalcitonin (PCT) and C-reactive protein (CRP) will be effective in reducing the length of antibiotic treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCommunity Acquired Pneumonia
CountriesNetherlands
CollaboratorsForeest Medical School, Pulmoscience

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedOct 17, 2013
Enrollment StartDec 5, 2013
Primary CompletionJan 20, 2017
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 12.7 years ago

Interventions

Discontinuation of treatment according to CRP levelsdrug

The cutoff point is a CRP below 100 mg/L and a reduction to 50% of the initial value.

Discontinuation of treatment according to PCT levelsdrug

The cutoff point is a PCT below 0.25 mcg/L or a reduction to 10% of the initial value.

Treatment according to current guidelinesdrug

Often a 7 days course of antibiotics, treatment may be extended if the attending physician deems it necessary.