CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 23 enrolled
Drug / intervention
Placeboother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01970943
NCT01970943N/ACompleted
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Molecular and Functional PET-fMRI Measures of Analgesia in Migraine

Massachusetts General Hospital·interventional·Posted Oct 28, 2013·Updated May 17, 2019

In Brief

A clinical study evaluating Placebo for Migraine and Healthy. Completed, enrolled 23 participants across 1 site.

Detailed Summary

The placebo effect is a phenomenon that has experienced major advances of its understanding in the last decade. However, mechanisms of placebo analgesia in chronic pain patients have yet to be compared to healthy subjects. The investigators study aims to investigate the magnitude of placebo response and related opioid release in patients that suffer from episodic migraines as compared to healthy controls. In particular, the investigators are looking to map brain activity during placebo analgesia using modern brain imaging techniques such as functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET). The investigators hypothesis is that placebo response and the availability of opioid receptors is reduced in chronic migraine patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMigraine, Healthy
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH), National Center for Complementary and Integrative Health (NCCIH)

Timeline

N/ACompletedFinished
20132014201520162017201820192020202120222023202420252026
First PostedOct 28, 2013
Enrollment StartSep 1, 2012
Primary CompletionApr 30, 2014
Study CompletionOct 30, 2017
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 12.7 years ago

Interventions

Placeboother

Placebo will be compared to No Intervention.